Antipyretic and anti-inflammatory effects and quality evaluation of a new type of Lonicera Japonicae Flos granule raw decoction piece
10.16438/j.0513-4870.2023-1434
- VernacularTitle:金银花新型颗粒饮片的质量评价及解热抗炎作用研究
- Author:
Zhi-jun GUO
1
;
Meng-meng HOU
2
;
Dan GAO
2
;
Yu-han WU
2
;
Ze-min YANG
2
;
Jia-lu WANG
2
;
Bo GAO
3
;
Xi-wen LI
2
Author Information
1. China Resources Sanjiu Medical & Pharmaceutical Co., Ltd., Shenzhen 518110, China; Anhui Provincial Key Laboratory of Traditional Chinese Medicine Formula Granule, Huaibei 235000, China
2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
3. Anhui Provincial Key Laboratory of Traditional Chinese Medicine Formula Granule, Huaibei 235000, China; China Resources Sanjiu Modern Chinese Medicine Pharmaceutical Co., Ltd., Huizhou 516000, China
- Publication Type:Research Article
- Keywords:
Lonicerae Japonicae Flos;
granule decoction pieces;
fingerprint;
standard decoction;
pharmacologic effect
- From:
Acta Pharmaceutica Sinica
2024;59(7):2087-2097
- CountryChina
- Language:Chinese
-
Abstract:
Traditional decoction pieces have low efficiency, poor batch-to-batch consistency, and irregular physical form, making it difficult to meet the demands of modern automated production and precise and rapid clinical blending. Therefore, this study aims to develop a new type of granular drinking tablet to meet the demand for high-quality development in the traditional Chinese medicine industry. In the current study, the differences and similarities between the new Lonicerae Japonicae Flos (LJF) granular drinking tablets and the traditional ones were evaluated based on the flowability, the paste rate of the standard soup, the characterization fingerprint, the degree of pasting, the content of active ingredients, the transfer rate, and its traditional antipyretic and anti-inflammatory efficacy, using the traditional LJF decoction piece as a reference. The flowability experiments showed that the flowability of medium-sized granules (10-24 mesh) was significantly better than that of traditional drinking tablets (P < 0.01); the results of the paste rate showed that there was no significant difference between the different particle sizes and the original decoction pieces (P > 0.05), but the small particle sizes (24-65 mesh) had poor decoction clarity and gelatinization; the transfer rate was calculated as chlorogenic acid and luteoloside, and there was no significant difference in the transfer rate between traditional slices and different particle sizes (P > 0.05); the pharmacological results showed that the contents of rat tumor necrosis factor-α (TNF-α), rat interleukin-1β (IL-1β) and rat prostaglandin E2 (PGE2), xylene ear swelling inhibition rate and granuloma inhibition rate showed that there was no significant difference between the traditional and new granule decoction pieces (P > 0.05). In this study, by examining the fluidity, paste rate, paste degree, and antipyretic and anti-inflammatory effects of the new granular decoction piece of LJF, it was initially revealed that the new granular drinking tablets of LJF were consistent with the basic properties and pharmacological effects of the commercially available traditional drinking tablets. Still, the new granular tablets were characterized by high utilization rate, homogeneous quality, and ease of clinical transfer, which had a good prospect for application. The animal experiment was approved by the Ethics Committee of the China Academy of Chinese Medical Sciences (approval number. 2022B214).
