A new furan α-butenolactones from Alisma orientale and their potential antifibrotic activities
10.16438/j.0513-4870.2023-1368
- VernacularTitle:东方泽泻中一个新的呋喃α-丁烯内酯及其潜在的抗肺纤维化活性
- Author:
Deng-hui ZHU
1
;
Peng-li GUO
1
;
Si-qi TAO
1
;
Jing-ke ZHANG
1
;
Meng-nan ZENG
1
;
Xiao-ke ZHENG
2
;
Wei-sheng FENG
2
Author Information
1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
2. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan Province and Ministry of Education of China, Zhengzhou 450046, China
- Publication Type:Research Article
- Keywords:
italic>Alisma orientale;
furan α-butenolactone;
structure identification;
antifibrotic
- From:
Acta Pharmaceutica Sinica
2024;59(7):2058-2061
- CountryChina
- Language:Chinese
-
Abstract:
Four furan α-butenolactones were isolated from 50% acetone extract of tuber of Alisma orientale by silica gel column, chromatography gel column and high performance liquid chromatography techniques. Their structures were identified by modern wave spectroscopy techniques and electronic circular dichroism (ECD) and assigned as (5R)-5-hydroxy-3,4-dimethylfuran-2(5H)-one (1), 5-hydroxy-3,5-dimethylfuran-2(5H)-one (2), 5-hydroxy-4-(1-methylethyl)-2(5H)-furanone (3) and alismanoid A (4). Compound 1 was new compound and compounds 2–4 were first isolated from Alisma orientale. Compound 1-4 had potential antifibrotic activities.
