Research progress of membrane biomimetic nanoparticles traversing the blood-brain barrier to treat brain diseases
10.16438/j.0513-4870.2023-0910
- VernacularTitle:膜仿生纳米制剂穿越血脑屏障治疗脑部疾病的研究进展
- Author:
Hui LIU
1
;
Hong-bin XU
2
;
Jian-qing GAO
3
;
Xin-chi JIANG
3
Author Information
1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
2. Ningbo First Hospital, Ningbo University, Ningbo 315010, China
3. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou 310058, China; State Key Laboratory of Advanced Drug Delivery and Release Systems, Hangzhou 310058, China
- Publication Type:Research Article
- Keywords:
membrane biomimetic nanoparticle;
blood-brain barrier;
cell membrane coating technique;
brain disease;
brain delivery
- From:
Acta Pharmaceutica Sinica
2024;59(7):1932-1941
- CountryChina
- Language:Chinese
-
Abstract:
At present, brain disease has become a "killer" in the field of general health, and the existence of blood-brain barrier has become one of the challenges in drug delivery into the brain. According to studies, cell membrane coating technique can endow nanoparticles with the characteristics of immune escape, long circulation, targeted delivery, and so on. Therefore, membrane biomimetic nanoparticles have been widely used in the field of disease treatment. Among them, the cell membrane derived from immune cells, tumor cells, and stem cells can cross the blood-brain barrier through the transcellular pathway and cell bypass pathway, which is used to prepare biomimetic membrane nanoparticles to break through the blood-brain barrier to achieve the treatment of brain diseases. What's more, the brain targeted ability of biomimetic nanoparticles would be further enhanced by modifying the cell membrane with peptides. This paper introduces the preparation methods of membrane biomimetic nanoparticles, expounds in detail the way that cell membrane coated nanoparticles break through the blood-brain barrier and achieve efficient intracerebral drug delivery. It also summarizes the prospects and challenges of this novel drug delivery system in the treatment of brain diseases, providing a reference for the research of membrane biomimetic nanoparticles in the treatment of brain diseases.
