Three new sesquiterpenes from Xylopia vielana Pierre and their effects of farnesoid X receptor activation
10.16438/j.0513-4870.2023-1248
- VernacularTitle:木瓣树中3个新的倍半萜类化合物及其法尼醇X受体激活作用研究
- Author:
Ya-ling WANG
1
;
Lin CHEN
1
;
Fan-cheng MENG
1
;
Min CHEN
1
;
Guo-wei WANG
1
Author Information
1. Southwest University College of Pharmaceutical Science
- Publication Type:Research Article
- Keywords:
italic>Xylopia vielana Pierre;
chemical constituent;
sesquiterpene;
farnesoid X receptor
- From:
Acta Pharmaceutica Sinica
2024;59(5):1341-1347
- CountryChina
- Language:Chinese
-
Abstract:
Eleven compounds were isolated from the twigs and leaves of Xylopia vielana Pierre by various chromatographic techniques such as silica gel, ODS and the semi-preparative HPLC. Their chemical structures were identified by HR-ESI-MS, NMR, ECD and other spectroscopic methods as vielana A (1), vielana B (2), vielana C (3), 10-oxo-isodauc-3-en-15-al (4), 1α-hydroxyisodauc-4-en-15-al (5), mokko lactone (6), 11β,13-dihydrocostunolide (7), eurylosesquiterpenol E (8), epi-α-cadinol (9), mustakone (10), 7-epi-amiteo (11). Among them, compounds 1-3 were new compounds, and the rest compounds were isolated from this plant for the first time. Compounds 1 and 2 increased the transcriptional activity of the farnesoid X receptor (FXR) downstream target gene BSEP promoter, indicating that they have potential of FXR activation.
