Research Progress of Sonic Hedgehog Signaling Pathway Involved in Intervertebral Disc Degeneration
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20241021.003
- VernacularTitle:Sonic Hedgehog信号通路参与椎间盘退变的研究进展
- Author:
Yong LIU
1
;
Haihong ZHANG
Author Information
1. 兰州大学第二医院骨科,甘肃兰州 730030
- Keywords:
intervertebral disc degeneration;
Sonic Hedgehog;
nucleus pulposus cell;
notochord cell;
glioma-associated oncogene homologue
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(6):968-975
- CountryChina
- Language:Chinese
-
Abstract:
With the intensification of aging society,more and more patients are troubled by low back pain,which brings burden to patients and society. Intervertebral disc degeneration (IVDD) is the main cause of chronic low back pain. Clarifying the pathogenic mechanism of IVDD is of great significance to solve the current health problems. In recent years,there have been a lot of reports on the role of the Sonic Hedgehog (Shh) pathway in IVDD. Shh signaling pathway plays an important role in the formation and postnatal maintenance of intervertebral disc,and the expression change of this pathway is accompanied by age-related degenerative changes of intervertebral disc. Targeting the Shh signaling pathway may have important implications in IVDD treatment. This review summarizes the research progress of Shh signaling pathway in IVDD,attempts to explore the possible relationship between this signaling pathway and various known pathologies of IVDD,and looks forward to future research content,in order to provide reference for exploring effective treatment and prevention methods of IVDD.
