Recent advance on the dissolution and absorption of the cocrystals of poorly soluble drugs
10.16438/j.0513-4870.2024-0122
- VernacularTitle:难溶性药物共晶的溶出与吸收研究进展
- Author:
Shao-zheng ZHANG
1
;
Shi-yu SHAN
1
;
Min-shan GUO
1
;
Ting CAI
2
Author Information
1. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
2. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China; School of Engineering, China Pharmaceutical University, Nanjing 211198, China; Engineering Research Center of Intelligent Pharmaceutical Key Technology, Ministry of Education, China Pharmaceutical University, Nanjing 211198, China
- Publication Type:Research Article
- Keywords:
pharmaceutical cocrystal;
poorly soluble drug;
phase transformation;
italic>in vitro dissolution;
italic>in vivo adsorption
- From:
Acta Pharmaceutica Sinica
2024;59(8):2205-2215
- CountryChina
- Language:Chinese
-
Abstract:
Pharmaceutical cocrystals are one of the effective strategies to improve the solubility and bioavailability of poorly water-soluble drugs. However, the phase transformation of cocrystals during dissolution can lead to the recrystallization of the parent drugs, and thus negating the solubility advantage of cocrystals. The introduction of suitable excipients into the cocrystal formulation may inhibit the phase transformation during dissolution, resulting in the enhanced dissolution and bioavailability of poorly soluble drugs. In addition, the complex gastrointestinal environment and absorption behavior of drugs can have significant impacts on the oral bioavailability of cocrystals. This review summarizes the recent studies of the dissolution and absorption of pharmaceutical cocrystals, and aims to provide guidance for the rational design of pharmaceutical cocrystal formulations.
