Chemical constituents of dichloromethane extract from the stems of Ephedra intermedia
10.16438/j.0513-4870.2024-0168
- VernacularTitle:中麻黄二氯甲烷萃取部位化学成分研究
- Author:
Xi-ling FAN
1
;
Yan-gang CAO
1
;
Xiao-ke ZHENG
2
;
Zhen-zhong WANG
3
;
Wei XIAO
3
;
Wei-sheng FENG
2
Author Information
1. Henan University of Chinese Medicine, Zhengzhou 450046, China; Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
2. Henan University of Chinese Medicine, Zhengzhou 450046, China; Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan Province and Ministry of Education of China, Zhengzhou 450046, China
3. State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Lianyungang 222001, China
- Publication Type:Research Article
- Keywords:
italic>Ephedra intermedia;
chemical constituents;
italic>β-hexosaminidase release rate
- From:
Acta Pharmaceutica Sinica
2024;59(9):2574-2580
- CountryChina
- Language:Chinese
-
Abstract:
Ten compounds were isolated and purified from the dichloromethane extract of stems of Ephedra intermedia by various chromatographic methods. Based on the analysis of physicochemical properties and spectral data, the structures of the ten compounds were identified as 1-allyl-3,4-dimethoxy-benzene-5-O-β-D-glucopyranoside (1), lyoniresinol (2), secoisolariciresinol (3), 4,3′,4′-trihydroxy-3-methoxylignan-9,9′-diyldiacetate (4), dehydroconiferyl alcohol (5), isocubebin (6), balanophonin B (7), sesquipinsapol B (8), crataegifin A (9), 1-(2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydrobenzofuran-5-yl)ethan-1-one (10). Compound 1 is a new compound, named as 1-allyl-3,4-dimethhoxy-benzene-5-O-β-D-glucopyranosyl, compounds 2-10 are lignans and isolated from this plant for the first time. Compound 3, 4, 8 possess potentially anti-asthmatic activities.
