A new abietane diterpene from the Styrax
10.16438/j.0513-4870.2024-0399
- VernacularTitle:苏合香中一个新的松香烷二萜
- Author:
Jie-nan FENG
1
;
Yong-xian CHENG
1
Author Information
1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China
- Publication Type:Research Article
- Keywords:
Styrax;
resin;
abietane diterpenes;
extraction and separation;
structural identification
- From:
Acta Pharmaceutica Sinica
2024;59(10):2836-2841
- CountryChina
- Language:Chinese
-
Abstract:
Twelve abietane diterpenes were isolated from the 95% ethanol fraction solvated from the aqueous extract of Styrax by using various chromatographic methods, including MCI Gel CHP 20P, Sephadex LH-20, ODS, silica gel, TLC and semi-preparative HPLC. The structures of the isolated compounds were identified by spectroscopy methods (1D, 2D NMR, UV, MS, etc.), and the absolute configuration of the new compound was determined by ECD calculations. Compound 1 is a new compound, which was identified as (4R,5R,9S,10R,12S)-12-methoxy-neoabietic acid, and compounds 2-12 were isolated from Styrax for the first time.
