The activity and mechanism of action of a novel Candida albicans biofilm inhibitor IMB-H12
10.16438/j.0513-4870.2023-1220
- VernacularTitle:新型白念珠菌生物被膜抑制剂IMB-H12的活性和作用机制研究
- Author:
Dan LI
1
;
Xiao-hong ZHU
2
;
Cong BIAN
2
;
Yuan-juan WEI
2
;
Wen-jing SHI
2
;
Yan LI
2
;
Li-jie YUAN
1
Author Information
1. Hebei Key Laboratory for Chronic Diseases, Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China
2. Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
italic>Candida albicans;
biofilm;
1-(cyclopentylamino)-3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propan-2-ol;
adhere;
hyphae
- From:
Acta Pharmaceutica Sinica
2024;59(4):948-956
- CountryChina
- Language:Chinese
-
Abstract:
italic>Candida albicans (C. albicans) stands as the primary opportunistic fungal pathogen responsible for fungal infections. The formation of biofilms constitutes a key virulence trait of C. albicans and a pivotal factor in drug resistance. Consequently, the development of antifungal drugs possessing biofilm inhibitory properties holds importance in the treatment of fungal infectious diseases. This study conducted in-depth research of the novel biofilm inhibitor named 1-(cyclopentylamino)-3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propan-2-ol (IMB-H12). IMB-H12 showed good inhibitory activity on the formation of biofilms and a certain scavenging effect on mature biofilms. Preliminary research on the mechanism of action has found that IMB-H12 can inhibit the transformation from yeast to hyphal phase, inhibit the formation of mycelium, and reduce the adhesion activity and hydrophobicity of Candida albicans. IMB-H12 could also induce changes in the content of cell wall components, downregulate the expression of multiple genes related to adhesion and hyphal formation. Therefore, further research on this compound is expected to discover new lead compounds with antifungal activity.
