Three new sesquiterpenoids from the Alpiniae oxyphyllae Fructus
10.16438/j.0513-4870.2023-1114
- VernacularTitle:益智仁中三个新的倍半萜类化合物
- Author:
Bo-tao LU
1
;
Yue-tong ZHU
1
;
Xiao-ning LIU
1
;
Hui-ying NIU
1
;
Meng-yu ZHANG
1
;
Wei-sheng FENG
2
;
Yan-zhi WANG
2
Author Information
1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
2. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Zhengzhou 450046, China
- Publication Type:Research Article
- Keywords:
italic>Alpinia oxyphylla Miq;
chemical composition;
separation and identification;
italic>seco-eudesmane sesquiterpenoid;
eremophilane sesquiterpenoid
- From:
Acta Pharmaceutica Sinica
2024;59(4):997-1001
- CountryChina
- Language:Chinese
-
Abstract:
The n-butanol fraction of Alpinia oxyphylla Fructus 70% ethanol extract was separated and purified using column chromatography with MCI Gel CHP-20, Sephadex LH-20, ODS, and silica gel, combined with semi preparative liquid phase and TLC separation methods. One new halogenated 4,5-seco-eudesmane sesquiterpenoid and two new eremophilane sesquiterpenoids were isolated and purified from the n-butanol fraction of Alpinia oxyphylla Fructus. The structures of the isolated compounds were identified using modern spectroscopic methods (1D, 2D NMR, UV, IR, MS, etc.), and the absolute configuration of the new compounds were determined using the methods of calculated ECD and induced ECD.
