Research progress of the protection provided by traditional Chinese medicine on non-alcoholic fatty liver disease via regulating liver macrophages
10.16438/j.0513-4870.2023-1100
- VernacularTitle:中药通过调控肝脏巨噬细胞防治非酒精性脂肪性肝病的研究进展
- Author:
Ke-ke WANG
1
;
Wang-ya JIA
1
;
Zhen-lin HUANG
1
;
Jian LI
2
;
Hong XU
1
;
Li-li JI
1
Author Information
1. The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2. China Pharmaceutical University, Nanjing 210009, China; Technology Center of Jinling Pharmaceutical Co., Ltd., Nanjing 210009, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver disease;
traditional Chinese medicine;
traditional Chinese medicine compound;
active compound;
macrophage
- From:
Acta Pharmaceutica Sinica
2024;59(4):801-810
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease (NAFLD) is a pathological syndrome characterized by the excessive deposition of lipids in hepatocytes but not caused by alcohol and other definite liver damage factors. The pathogenesis of NAFLD is complex. When the liver is damaged, a large amount of lipids deposited in hepatocytes will induce oxidative stress injury, endoplasmic reticulum stress and metabolic disorders in hepatocytes, and immune cells further secrete inflammatory cytokines and release them into the blood, causing systemic inflammation. In the process of NAFLD, the inflammatory response plays an important role. Macrophages are the most abundant non-parenchymal cells in the liver and play an important role in liver inflammatory injury. Hepatic macrophages include liver-native and monocyte-derived macrophages, and their activation and polarization processes are involved in the different development stages of NAFLD. Traditional Chinese medicine (TCM) compound and its active compounds have been found to regulate macrophages to participate in the process of inflammation, injury and recovery of NAFLD. Based on the existing research reports, this paper elaborates the relationship between the source, activation and polarization of macrophages and NAFLD as the breakthrough point, and systematically reviews the mechanism of TCM in the prevention and treatment of NAFLD by regulating the activation, recruitment and polarization of macrophages. This paper aims to provide new ideas for the discovery of novel NAFLD candidate drugs from TCM via targeting macrophages.
