A new aurone glycoside from the whole plant of Bidens pilosa L.
10.16438/j.0513-4870.2023-1327
- VernacularTitle:鬼针草全草中一个新的橙酮苷类化合物
- Author:
Chang LIU
1
;
Yu HAN
2
;
Jiao LIU
2
;
Tao ZHANG
3
;
Zhong-mei ZOU
1
Author Information
1. Henan University of Chinese Medicine, Zhengzhou 450046, China; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China; Shenyang Pharmaceutical University, Shenyang 110016, China
3. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
- Publication Type:Research Article
- Keywords:
Asteraceae;
italic>Bidens pilosa L.;
chemical composition;
aurone;
hypolipidemic activity
- From:
Acta Pharmaceutica Sinica
2024;59(6):1757-1764
- CountryChina
- Language:Chinese
-
Abstract:
Ten compounds were isolated from the 95% ethanol extract of the whole plant of Bidens pilosa L. by silica gel column chromatography, polyamide column chromatography, Sephadex LH-20 column chromatography, MCI column chromatography, and semi-preparative HPLC methods. Based on its physicochemical properties and spectral data (UV, IR, MS, NMR), the structures of the isolates were identified as bidpilaurone glycoside A (1), Z-6-O-(4″-O-acetyl-6″-O-p-coumarinyl-β-D-glucopyranosyl)-6,7,3′,4′-tetrahydroxyaurone (2), okanin 4′-O-β-D-(4″,6″-diacetyl) glucopyranoside (3), Z-6-O-(6″-O-acetyl-β-D-glucopyranosyl)-6,7,3′,4′-tetrahydroxyaurone (4), 6,7,3,4′-tetrahydroxyaurone (5), Z-6-O-(6-O-coumarinyl-β-D-glucopyranosyl)-6,7,3′,4′-tetrahydroxyaurone (6), Z-6-O-(4,6-acetyl-β-D-pyranosyl)-6,7,3,4′-tetrahydroxyaurone (7), Z-6-O-(6″-O-p-coumarinyl-β-D-glucopyranosyl)-6,7,3′,4′-tetrahydroxyaurone (8), luteolin (9), and 7-O-β-D-glucopyranosyl-5,3′-dihydroxy-3,6,4′-trimethoxyflavone (10). Among them, compound 1 was a new aurone glycoside from B. pilosa L. Compounds 4 and 9 could partially inhibit the lipid deposition induced by sodium oleate and palmitate in human liver HepG2 cells. Molecular docking technology predicts that the potential target for its hypolipidemic activity may be peroxisome proliferator-activated receptors γ (PPARγ).
