New advances in stroke therapy targeting the CREB signaling pathway and the potential for herbal interventions
10.16438/j.0513-4870.2023-1308
- VernacularTitle:基于CREB信号通路的脑卒中治疗中药研究进展
- Author:
Cui-cui CHENG
1
;
Yu-juan LIANG
1
;
Xing LI
2
;
Ming LÜ
1
;
Yan ZHU
1
Author Information
1. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
2. Guizhou Bailing Group Pharmaceutical Co., Ltd., Guiyang 550000, China
- Publication Type:Research Article
- Keywords:
stroke;
cAMP response element binding protein;
synaptic plasticity;
apoptosis;
traditional Chinese medicine
- From:
Acta Pharmaceutica Sinica
2024;59(6):1538-1545
- CountryChina
- Language:Chinese
-
Abstract:
cAMP response element binding protein (CREB) is an eukaryotic intranuclear protein widely expressed in a variety of organs, and its activation increases the transcriptional activity of downstream genes and promotes the expression of related genes. The neuronal function of CREB is related to many intracellular processes, such as proliferation, differentiation, survival, long-term synaptic potentials, neurogenesis and neuronal plasticity. Increasing evidence has demonstrated that CREB plays an important role in the stroke development and therefore, it may serve as a potential target for stroke therapy. Since some herbal medicines as well as their active ingredients regulate the CREB signaling, this article will summarize the role of CREB signaling pathway in stroke pathophysiology. The research progress of traditional Chinese medicine and its active ingredients modulating CREB activity will also be discussed, with the aim of providing the basis and reference for the future research and development of natural medicines against stroke.
