A new biphenyl lignan from Cornus officinalis
10.16438/j.0513-4870.2023-1305
- VernacularTitle:山茱萸中的一个新联苯类木脂素
- Author:
Meng YANG
1
;
Zhi-you HAO
1
;
Xiao-lan WANG
2
;
Shi-qi ZHOU
1
;
Chao-yuan XIAO
1
;
Jun-yang ZHANG
1
;
Xiao-ke ZHENG
1
;
Wei-sheng FENG
3
Author Information
1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
2. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
3. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China; Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry, Zhengzhou 450046, China
- Publication Type:Research Article
- Keywords:
italic>Cornus officinalis;
chemical constituent;
neolignan B;
biphenyl lignan;
isolation and identification
- From:
Acta Pharmaceutica Sinica
2024;59(6):1751-1756
- CountryChina
- Language:Chinese
-
Abstract:
Macroporous adsorption resin, MCI, Toyopearl HW-40C and silica gel column chromatography combined with the semi-preparative HPLC were used to isolate and purify the water extract of Cornus officinalis. And the structures of compounds were identified by HRESIMS, NMR, IR, UV and ECD. A total of twelve compounds were isolated from the fruits of Cornus officinalis. They were identified as neolignan B (1), 2,3-dihydro-7-methoxy-2-(4′-hydroxy-3′-methoxyphenyl)-3a-O-β-D-xylopyranosyloxymethyl-5-benzofuranpropanol (2), cornucadinoside A (3), 3,4-dihydroxyacetophenone (4), n-butyl gallate (5), 3-hydroxybenzoic acid (6), n-butyl quininate (7), 5-hydroxymaltol (8), 2-furolic acid (9), 5-hydroxymethylfurfural (10), 5-(methoxycarbonyl)-2-pyrrolidone (11), and dimethyl malate (12). Compound 1 is a new biphenyl lignan, named as neolignan B. Compounds 2, 4, 5, 7-9 and 11 were isolated from Cornus officinalis for the first time.
