Targeting platelet-immune cell interaction as a new strategy for post-myocardial infarction current evidence and future prospective
10.16438/j.0513-4870.2023-0124
- VernacularTitle:靶向血小板-免疫细胞相互作用作为心肌梗死后治疗的新策略——当前证据和未来展望
- Author:
Lin-hong HAN
1
;
Yu-han ZHAO
1
;
Xiao-ying WANG
2
;
Yan ZHU
1
Author Information
1. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China
2. Department of Neurosurgery, Center for Clinical Neuroscience Research, Tulane University School of Medicine, New Orleans 70112, USA
- Publication Type:Research Article
- Keywords:
myocardial infarction;
inflammation;
blood platelet;
immune cell;
communication
- From:
Acta Pharmaceutica Sinica
2024;59(6):1519-1526
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction (MI) is a fatal disease with high morbidity and mortality. Platelets are major players of thrombosis and inflammation after acute myocardial infarction. There is growing evidence that platelets mediate inflammation, participate in dead tissue removal and heart remodeling through direct or indirect interactions with immune cells post-MI. This paper reviews the type of interactions between platelets and immune cells after myocardial infarction, and summarizes the mechanism of platelet interaction with different immune cells, such as neutrophils, monocytes, and macrophages, to mediate cardiac injury and repair through up-regulation of surface receptors and release of immune regulatory mediators post-MI. Therapeutic strategies targeting the interaction between platelets and immune cells for myocardial infarction is also presented, to provide reference for the exploration of new immune therapy targets for myocardial infarction.
