Research progress on the role and mechanism of extracellular matrix in aortic aneurysm and dissection
- VernacularTitle:细胞外基质在主动脉瘤和主动脉夹层中的作用及机制研究进展
- Author:
Ting TIAN
1
;
Fan LUO
1
;
Liping ZHAO
1
;
Junyi LUO
1
;
Fen LIU
1
,
2
;
Yining YANG
2
,
3
,
4
Author Information
1. Heart Center, The First Affiliated Hospital of Xinjiang University, Urumqi, 830054, P. R. China
2. State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi, 830054, P. R. China
3. Department of Cardiology, People s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, P. R. China
4. Xinjiang Key Laboratory of Cardiovascular Homeostasis and Regeneration Research, Urumqi, 830001, P. R. China
- Publication Type:Journal Article
- Keywords:
Aortic dissection;
aortic aneurysm;
extracellular matrix;
vascular remodeling;
review
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2024;31(09):1376-1384
- CountryChina
- Language:Chinese
-
Abstract:
Aortic aneurysm and dissection are critical cardiovascular diseases that threaten human life and health seriously. No pharmacological treatment can effectively prevent disease progression. The imbalance of aortic wall cells and non-cellular components leads to structural or functional degeneration of the aorta, which is a prerequisite for disease occurrence. As the important non-cellular component, extracellular matrix (ECM) is crucial to maintain the aortic structure, function, and homeostasis. Abnormal production of elastin and collagen, destruction of cross-linking between elastic fibers and collagen fibers, and the imbalance of metalloproteinase and inhibitors leads to excessive degradation of ECM proteins, all of which have destroyed the structure and function of aorta. It will provide more ideas for disease prevention and treatment by learning ECM proteins and their metabolic mechanism. Here, we focus on the ECM proteins that have been reported to be involved in aortic aneurysm and dissection, and discuss the regulatory mechanism of metalloproteinase and inhibitors.
