Arrhythmia induced by clozapine in patients with schizophrenia:a Meta-analysis
10.11886/scjsws20231211002
- VernacularTitle:氯氮平致精神分裂症患者心律失常的Meta分析
- Author:
Yadi CHEN
1
;
Yu DING
;
Qianqian LI
;
Xiaolei LIU
;
Weiwei WANG
Author Information
1. 昆明医科大学第二附属医院,云南 昆明 650033
- Keywords:
Clozapine;
Schizophrenia;
Arrhythmias;
Meta-analysis
- From:
Sichuan Mental Health
2024;37(5):475-481
- CountryChina
- Language:Chinese
-
Abstract:
Background Clozapine belongs to atypical antipsychotic drugs that has shown significant efficacy in treating schizophrenia.However,clozapine can induce arrhythmias in patients.Currently,there is a lack of systematic research on the types and incidence of clozapine-induced arrhythmias.Objective To explore the types and incidence of arrhythmias in patients with schizophrenia induced by clozapine through Meta-analysis,so as to provide references for clinical treatment.Methods On October 31,2022,a search was conducted through PubMed,Embase,Cochrane Library and China National Knowledge Infrastructure(CNKI)to collect relevant literature on clozapine-induced arrhythmia in patients with schizophrenia.Joanna Briggs Institute(JBI)was used to evaluate the quality of the included literature.Meta-analysis was conducted using Review Manager 5.4.Results A total of 12 studies were included,involving 42 490 schizophrenia patients taking clozapine.The incidence of arrhythmias caused by clozapine was 23％(95％CI:0.16～0.29).Among them,the incidence of tachycardia was 25％(95％CI:0.15～0.35),atrial arrhythmia was 6％(95％CI:-0.02～0.14),ventricular arrhythmia was 7％(95％CI:-0.02～0.16),conduction block was 2％(95％CI:0～0.04),QTc prolongation was 4％(95％CI:-0.04～0.12)and T-wave changes was 23％(95％CI:0.16～0.30).Conclusion Schizophrenia patients taking clozapine may increase their risk of developing arrhythmia,with tachycardia being the most prevalent.
