Relationship between Insulin Resistance and Circulating Levels of Monocyte Chemoattractant Protein?1 in Healthy Adults.
- Author:
Joo Ho YOON
1
;
Hee Jeong CHOI
;
Kyung Sun YOON
;
Sang Hwan KIM
Author Information
1. Department of Family Medicine, Eulji University Hospitial, Eulji University School of Medicine, Daejeon, Korea. fanin@eulji.ac.kr
- Publication Type:Original Article
- Keywords:
MCP-1;
insulin resistance;
HOMA-IR;
atherosclerosis
- MeSH:
Adult;
Atherosclerosis;
Blood Pressure;
Body Mass Index;
Chemokine CCL2;
Cholesterol;
Fasting;
Glucose;
Glycosaminoglycans;
Homeostasis;
Humans;
Insulin;
Insulin Resistance;
Linear Models;
Medical Records;
Monocytes;
Triglycerides
- From:Journal of the Korean Academy of Family Medicine
2008;29(3):189-194
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Insulin resistance is one of the underlying causes for atherosclerosis. The monocyte chemoattractant protein-1 (MCP-1) plays a crucial role in initiating atherogenesis by recruiting monocytes/macrophages to vessel wall. In this study, we investigated the relationship between homeostasis model assessment-estimated insulin resistance (HOMA-IR) and circulating level of MCP-1 in healthy adults. METHODS: By reviewing the medical records of 171 healthy adults, we determined the circulating level of MCP-1, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, LDL- cholesterol, HDL-cholesterol, fasting glucose, fasting insulin level and HOMA-IR. We studied the relationship between the variables by Pearson correlation coefficients and multiple linear regression analysis. RESULTS: MCP-1 correlated positively with HOMA-IR (r=0.28; P<0.01). Age, systolic blood pressure, diastolic blood pressure, triglycerides, LDL-cholesterol, fasting glucose and insulin level also showed stastically significant correlation. Age, gender, HOMA-IR were the variables which affected MCP-1 by multiple regression analysis adjusting for body mass index, systolic blood pressure, triglycerides, and LDL-cholesterol. CONCLUSION: In our study, circulating levels of MCP-1 were associated with insulin resistance. These findings support the potential role of MCP-1 as a biomarker for subclinical atherosclerosis.
