Multilayered Regulation of The Eukaryotic DNA Replication
10.16476/j.pibb.2024.0284
- VernacularTitle:真核细胞DNA复制的多层级调控
- Author:
Zheng-Rong ZHANG-DING
1
;
Yang LIU
1
;
Xu-Hao LIU
1
;
Jia-Zhi HU
1
Author Information
1. PKU-THU Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China
- Publication Type:Journal Article
- Keywords:
DNA replication;
chromatin environment;
multi-levels of regulation
- From:
Progress in Biochemistry and Biophysics
2024;51(10):2717-2729
- CountryChina
- Language:Chinese
-
Abstract:
DNA replication is a fundamental DNA metabolism process in living organisms. In human cells, thousands of DNA replication origins are activated simultaneously within the chromatin environment to initiate the replication process and eventually complete genome duplication. This process is regulated by the chromatin environment and coordinated with other chromatin metabolism events, ensuring accurate inheritance of genomic and epigenetic information. With the rapid development of research techniques and the massive accumulation of research data, the systematic understanding of DNA replication in eukaryotic cells, especially in mammals, within complex chromatin environments is a future research trend. Here, we review the multilayered regulatory modes of DNA replication from initiation to termination in the chromatin environment, offering insights for future research.
