Research Progress in Regulation of SRC Kinase on Tumor Glucose Metabolism
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240907.003
- VernacularTitle:SRC激酶调控肿瘤糖代谢的研究进展
- Author:
Yuwen GONG
1
;
Zhiping WANG
Author Information
1. 兰州大学第二医院泌尿外科//兰州大学第二医院泌尿外科研究所//甘肃省泌尿系统疾病研究重点实验室//甘肃省泌尿系统疾病临床医学中心,甘肃 兰州,730000
- Keywords:
SRC kinase;
glucose metabolism;
Warburg effect;
inhibitor;
tumor;
targeted therapy
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(5):755-763
- CountryChina
- Language:Chinese
-
Abstract:
SRC kinase is a membrane-associated non-receptor tyrosine kinase that plays an important role in cell growth,division,migration and survival signaling pathways.In addition,it regulates glucose metabolism in cancer cells through different mechanisms,such as direct regulation of glucose metabolism-related enzymes and glucose transporters,or indirect regulation of related signaling pathways.In this review,we elucidate the role of SRC kinase in the regulation of glucose metabolism in cancer cells,and also discuss the research advance of SRC inhibitors,to explore the development of more selective and active SRC inhibitors,so as to make the targeting SRC become a new hope for the treatment of tumors.
