Causal association between six metabolites and atopic dermatitis:a bidirectional two-sample Mendelian randomization study
- VernacularTitle:6种代谢产物与特应性皮炎的因果关联:双向双样本孟德尔随机化研究
- Author:
Yan WEI
1
;
Yan SUN
;
Lijuan WANG
;
Shuai SHAO
;
Yan ZHENG
Author Information
- Keywords: atopic dermatitis(AD); Mendelian randomization(MR); causal connection; metabolic factor; inverse variance weighted(IVW)
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2024;45(5):801-808
- CountryChina
- Language:Chinese
- Abstract: Objective We made a bidirectional two-sample Mendelian randomization(MR)analysis to investigate the causal connection between metabolites and atopic dermatitis(AD).Methods Single nucleotide polymorphic(SNP)sites associated with metabolites were extracted from the aggregated data of a genome-wide association study(GWAS)as instrumental variables.Causal association between six metabolites and AD was analyzed using the TwoSampleMR package in R software.The primary methods employed included inverse variance weighted(IVW),MR Egger,and weighted median.Heterogeneity testing was conducted using Cochran's Q statistics.MR Egger intercept was employed to test for level pleiotropy.Additionally,sensitivity analysis was carried out using the"leave-one-out"approach.Results The IVW analysis results indicated that ascorbic acid(OR=0.861,95％CI:0.751-0.987),arachidonic acid(OR=0.363,95％CI:0.193-0.683),and cortisone(OR=0.447,95％CI:0.221-0.906)were negatively correlated with the occurrence of AD,while uridine(OR=3.473,95％CI:1.043-11.562),serotonin(OR=1.896,95％CI:1.007-3.571),and 2-hydroxyglutaric acid(OR=2.158,95％CI:1.186-3.924)were positively correlated with the occurrence of AD,and the differences were statistically significant.Conclusion There is no significant evidence supporting a causal association between AD and metabolic disorder,but this study identified potential evidence for a causal effect of six metabolic factors on an increased risk of AD.
