Clinical Efficacy of Chaigui Zengmian Prescription for Recurrent Respiratory Tract Infections in Children with Syndrome of Qi Deficiency in Lung and Spleen
10.13422/j.cnki.syfjx.20242196
- VernacularTitle:柴桂增免方治疗儿童反复呼吸道感染肺脾气虚证的临床疗效
- Author:
Xueming CHEN
1
;
Ke WU
1
;
Shuai XU
1
;
Yan LIN
2
;
Lin JIA
2
Author Information
1. Graduate School of Hebei University of Traditional Chinese Medicine（TCM），Shijiazhuang 050091，China
2. The First Affiliated Hospital of Hebei University of TCM，Shijiazhuang 050011，China
- Publication Type:Journal Article
- Keywords:
Chaigui Zengmian prescription;
children with recurrent respiratory tract infections;
syndrome of Qi deficiency in lung and spleen;
clinical efficacy;
immune factor
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(19):139-143
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the clinical efficacy of Chaigui Zengmian prescription （composed of Bupleuri Radix， Codonopsis Radix， Scutellariae Radix， Cinnamomi Ramulus， Paeoniae Radix Alba， Astragali Radix， Atractylodis Macrocephalae Rhizoma， and Scorpio） in treating recurrent respiratory tract infections in children with syndrome of Qi deficiency in lung and spleen and the influences of this prescription on immune factors. MethodSixty-six children suffering from recurrent respiratory tract infections due to Qi deficiency in lung and spleen were selected and randomized into a control group （33 cases） and an observation group （33 cases）. The control group received spleen aminopeptide oral lyophilized powder and the observation group was treated with self-made Chaigui Zengmian prescription granules. Both groups were treated for two months （as two consecutive courses of treatment）. The traditional Chinese medicine （TCM） symptom scores and the serum levels of total immunoglobulins （IgA， IgM， and IgG） and T-helper cells （Th1， Th2， and Th1/Th2） were measured in both groups before and after treatment and then compared. Result① After treatment， the TCM symptom scores of both groups declined and the observation group had lower scores than the control group （P<0.05）. ② The observation group［87.50%（28/32）］ had higher total response rate than the control group［96.88%（31/32）］（Z=7.921，P<0.05）.Also the observation group［28.13%（9/32）］ had more cured children than the control group［6.25（2/32）］ （χ2=5.379，P<0.05） ③ After treatment， the serum levels of IgA， IgM， IgG， Th1， and Th1/Th2 elevated while that of Th2 declined （P<0.05）， and the changes were more obvious in the observation group than in the control group （P<0.05）. ConclusionChaigui Zengmian prescription is effective in treating recurrent respiratory tract infections in children with the syndrome of Qi deficiency in lung and spleen. It can alleviate the symptoms and rectify immune disequilibrium， demonstrating a clinical application value.
