Efficacy observation of cetrorelix combined with aspirin in preventing early-onset ovarian hyperstimulation syndrome
- VernacularTitle:西曲瑞克联合阿司匹林预防早发型卵巢过度刺激综合征的疗效观察
- Author:
Yingying ZHANG
1
;
Yile ZHANG
1
;
Hao SHI
1
;
Zhiqin BU
1
;
Li YANG
1
;
Yanlei MENG
1
;
Yihong GUO
1
Author Information
1. Reproductive Medical Center，Reproductive and Genetic Hospital，the First Affiliated Hospital of Zhengzhou University，Zhengzhou 450052，China
- Publication Type:Journal Article
- Keywords:
ovarian hyperstimulation syndrome;
cetrorelix;
aspirin;
long-lasting follicular phase protocol;
ovulation induction
- From:
China Pharmacy
2024;35(16):2009-2012
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the efficacy of cetrorelix combined with aspirin in preventing early-onset ovarian hyperstimulation syndrome （OHSS）. METHODS A retrospective analysis was conducted on clinical data from 38 early-onset OHSS patients， who received treatment in our hospital from January 1st to July 1st， 2022. These patients were divided into intervention group （19 cases） and control group （19 cases） according to the therapy regimen. On the first day after oocyte retrieval surgery， the control group was given aspirin enteric-coated tablets 100 mg orally until menstruation began. The intervention group was given cetrorelix for injection 0.25 mg subcutaneously， for consecutive 3 days+aspirin enteric-coated tablets （same usage and dosage as the control group）. The first luteal phase， the degree of OHSS， and the ovarian volume， ascites volume， serum estradiol （E2）， white blood cell count （WBC）， hematocrit （HCT）， neutrophil ratio （NEUT%）， D-dimer （DD）， prothrombin time （PT）， fibrinogen （Fib） after oocyte retrieval surgery were observed and measured in 2 groups. RESULTS The first luteal phase was significantly shorter， and the proportions of median and severe OHSS cases were significantly lower in the intervention group compared to the control group （P＜0.05 or P＜0.01）. After oocyte retrieval surgery， the intervention group showed significantly lower ovarian volume， ascites volume， serum E2， WBC， NEUT%， HCT， DD and Fib compared to the control group， but PT of intervention group was signiticantly higher than that of control group （P＜0.05）. CONCLUSIONS Cetrorelix combined with aspirin is more effective in preventing early-onset OHSS than aspirin alone.
