Research Progress on Gut Microbiota in Prader-Willi Syndrome

VernacularTitle:Prader-Willi综合征肠道微生态菌群研究进展
Author: Yu ZHOU ¹ ; Mingsheng MA
Author Information

1. 中国医学科学院北京协和医院儿科,北京 100730
Keywords: rare diseases; Prader-Willi syndrome; gut microbiota; obesity
From: JOURNAL OF RARE DISEASES 2024;3(3):375-380
CountryChina
Language:Chinese
Abstract: Prader-Willi syndrome(PWS)is a genetically imprinted disorder characterized by intellec-tual impairment,obesity,metabolic disorders,and behavioral abnormalities.The pathological mechanisms of metabolic disorders and behavioral abnormalities are not yet clear,and the treatment effect up to now is not satisfactory.In recent years,the role of gut microbiota in metabolic regulation has gradually been recognized.This article will systematically review the research progress of gut microbiota in PWS.Compared to healthy in-dividuals or other simply obese individuals.PWS patients show changes in the gut microbiota.The changes are related to metabolic disorders and inflammatory status in PWS patients.Intervention of gut microbiota through diet or probiotics has played a certain role in controlling weight and improving behavioral abnormalities in PWS patients.