Investigation the association between γδT cells with endometrial polyps
10.19405/j.cnki.issn1000-1492.2024.06.009
- VernacularTitle:育龄期妇女子宫内膜息肉中γδT细胞的表达及临床意义
- Author:
Zihan MENG
1
;
Yulu YANG
;
Huijuan ZOU
;
Xueke ZHANG
;
Wenjuan YANG
;
Dongying SUN
;
Xiaofeng XU
Author Information
1. 安徽医科大学第一附属医院妇产科,合肥 230032;国家卫生健康委配子及生殖道异常研究重点实验室,合肥 230032;出生人口健康教育部重点实验室,合肥 230032;生命资源保存与人工器官教育部工程研究中心,合肥 230032
- Keywords:
γδT cells;
endometrial polyps;
interleukin-17;
interferon-γ;
inflammatory reaction;
embryo implanta-tion failure;
infertility
- From:
Acta Universitatis Medicinalis Anhui
2024;59(6):971-976
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical value of γδT cells and related inflammatory factors in endometrial polyps(EP).Methods Subjects were patients with infertility due to EP(EP group,n=57)and infertility due to non-uterine factors(Control group,n=44).EP tissues and normal endometrial tissues were taken,respectively.The general characteristics of the two groups were evaluated by independent samples T-test or Wilcoxon rank sum test.The expressions of CD3 and TCRγδ in proliferative endometrium and endometrial polyps were observed by immunofluorescence,and the expressions of IL-17 and IFN-γ in tissue homogenate were detected by ELISA.Uni-variable linear regression was used to analyze the correlation between the number of γδT cells and the expression level of IL-17 and IFN-γ.Results Both the number of γδT cells and he levels of IL-17 and IFN-γsignificantly increased in endometrial polyp tissues,and the relationship between is linear(all P＜0.05).Conclu-sion γδT cells are associated with EP among infertile women,which may lead to embryo implantation failure by affecting the expression of inflammatory factors and regulating the imbalance of cell subsets.
- Full text:2024081421200207354育龄期妇女子宫内膜息肉中γδT细胞的表达及临床意义_孟子晗.pdf
