Molecular diagnostic strategies and management of dust mite allergy
10.3760/cma.j.cn112150-20231129-00384
- VernacularTitle:尘螨过敏的分子诊断策略及管理
- Author:
Hui GAN
1
;
Liting WU
;
Baoqing SUN
Author Information
1. 广州医科大学附属第一医院临床检验中心，广州呼吸健康研究院，国家呼吸系统疾病临床研究中心，国家呼吸医学中心，广州 510120
- Keywords:
Dust mite;
Allergies;
Component-resolved diagnosis;
Asthma
- From:
Chinese Journal of Preventive Medicine
2024;58(1):148-154
- CountryChina
- Language:Chinese
-
Abstract:
Dust mites are one of the most important allergens, widely distributed around the world, especially in household environments. Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis are the most common species of dust mites. There are more than 35 known sensitization components of dust mites, among which Der p 1, Der p 2 and Der p 23 are the major components. Clinically, allergen skin test and serum specific immunoglobulin E (sIgE) detection are widely used in the preliminary diagnosis of dust mite allergy. However, these methods cannot accurately identify specific dust mite sensitization components. Considering that there are significant differences in the allergenic components of dust mites in different regions and populations, component-resolved diagnosis of dust mite is particularly important in accurately determining the allergenic components. This is not only of guiding significance for allergen avoidance, but also important for determining the immunotherapy regimen for dust mites. In order to strengthen the understanding of the molecular diagnosis of dust mites and promote the integration of allergy science in China with the international standards, this article interprets the "Allergy Molecular Allergology User′s Guide 2.0" published recently by the European Academy of Allergy and Clinical Immunology.
