Controls of Nuclear Factor-Kappa B Signaling Activity by 5’-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells.
- Author:
Bo Hwa CHOI
1
;
Da Hyun LEE
;
Jin KIM
;
Ju Hee KANG
;
Chang Shin PARK
Author Information
- Publication Type:Review
- Keywords: NF-kappa B; AMP-Activated Protein Kinases; Lipopolysaccharides; Hypoxia
- MeSH: Acetylation; AMP-Activated Protein Kinases; Anoxia; Cell Line; Humans*; Lipopolysaccharides; Metformin; NF-kappa B; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Kinases*; Protein Processing, Post-Translational; Urinary Bladder Neoplasms*; Urinary Bladder*
- From:International Neurourology Journal 2016;20(3):182-187
- CountryRepublic of Korea
- Language:English
- Abstract: Generally, both lipopolysaccharide (LPS)- and hypoxia-induced nuclear factor kappa B (NF-κB) effects are alleviated through differential posttranslational modification of NF-κB phosphorylation after pretreatment with 5'-AMP-activated protein kinase (AMPK) activators such as 5'-aminoimidazole-4-carboxamide ribonucleotide (AICAR) or the hypoglycemic agent metformin. We found that AICAR or metformin acts as a regulator of LPS/NF-κB-or hypoxia/NF-κB-mediated cyclooxygenase induction by an AMPK-dependent mechanism with interactions between p65-NF-κB phosphorylation and acetylation, including in a human bladder cancer cell line (T24). In summary, we highlighted the regulatory interactions of AMPK activity on NF-κB induction, particularly in posttranslational phosphorylation and acetylation of NF-κB under inflammatory conditions or hypoxia environment.
