Genomic aspects in reproductive medicine
- Author:
Minyeon GO
1
;
Sung Han SHIM
Author Information
- Publication Type:Review Article
- From:Clinical and Experimental Reproductive Medicine 2024;51(2):91-101
- CountryRepublic of Korea
- Language:English
- Abstract: Infertility is a complex disease characterized by extreme genetic heterogeneity, compounded by various environmental factors. While there are exceptions, individual genetic and genomic variations related to infertility are typically rare, often family-specific, and may serve as susceptibility factors rather than direct causes of the disease. Consequently, identifying the cause of infertility and developing prevention and treatment strategies based on these factors remain challenging tasks, even in the modern genomic era. In this review, we first examine the genetic and genomic variations associated with infertility, and subsequently summarize the concepts and methods of preimplantation genetic testing in light of advances in genome analysis technology.
