Correlation analysis between HCY,LP-PLA2,RDW,and UA in ischemic stroke patients with H-type hypertension
10.19845/j.cnki.zfysjjbzz.2020.0325
- VernacularTitle:H型高血压伴急性脑梗死患者外周血HCY与LP-PLA2、RDW、UA变化及相关性分析
- Author:
Dan TAO
1
;
Xin HE
1
;
Yanyun WANG
1
Author Information
1. The First Hospital of Lanzhou University,Lanzhou 730000,China
- Publication Type:Journal Article
- Keywords:
H-type hypertension ； Acute cerebral infarction ； Inflammation ； Homocysteine(HCY) ； Lipoprotein associated phospholipase A2(Lp-PLA2)
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(4):298-301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of HCY and LP-PLA2,RDW,and UA in patients with H-type hypertension with acute cerebral infarction.Methods A total of 408 patients with acute cerebral infarction treated in the Department of Neurology,First Hospital of Lanzhou University from January 2017 to June 2019 were selected and divided into H type hypertension group (248 cases),HCY alone group (107 cases).The non-H hypertension group (31 cases),the simple acute cerebral infarction group (22 cases),and the healthy physical examination patients in the same period were selected as the control group (63 cases).Results (1)The levels of male,LP-PLA2,HCY,and RDW were significantly higher in the H-type hypertension group than in the simple acute cerebral infarction group and the normal control group(P<0.05);(2)HCY levels were significantly higher in men with H-type hypertension than women(P<0.05);(3)HCY was positively correlated with RDW and UA in the H-type hypertension group (r=0.389,P<0.001;r=0.171,P<0.001);(4)In the H-type hypertension group,HCY,LP-PLA2,RDW,and UA all have certain diagnostic efficacy (AUC=0.724,0.916,0.731),respectively,0.677 were less than the joint detection AUC=0.947.Conclusion HCY,LP-PLA2,RDW,and UA can prompt the inflammation status of H-type hypertension with acute cerebral infarction;H-type hypertension and LP-PLA2 levels have certain synergistic effect in acute cerebral infarction.
- Full text:202408021106433480Correlation analysis between HCY,LP-PLA2,RDW,and UA in ischemic stroke patients with H-type hypertension.pdf
