Expression of Angiopoietin-like protein 4 and its relationship with carotid atherosclerosis in patients with acute cerebral infarction
10.19845/j.cnki.zfysjjbzz.2020.0386
- VernacularTitle: 急性脑梗死患者血管生成素样蛋白4表达及与颈动脉粥样硬化之间关系
- Author:
Fang GUO
1
;
Chong ZHENG
1
;
Yingying TANG
1
Author Information
1. Department of Neurology,the First Affiliated Hospital of Fujian Medical University,Fujian Institute of Neurology,Fuzhou 350000,China
- Publication Type:Journal Article
- Keywords:
Acute cerebral infarction；Arteriosclerosis；Angiopoietin-like protein 4
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(6):527-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of angiopoietin-like protein 4 (ANGPTL4) in patients with acute cerebral infarction and the relationship between ANGPTL4 and carotid atherosclerosis.Methods 170 patients with acute cerebral infarction and 133 patients in the control group were selected.According to the results of carotid ultrasound,the cerebral infarction group was divided into three groups:non plaque group (26 cases),stable plaque group (40 cases) and unstable plaque group (104 cases).The serum level of ANGPTL4 was measured by enzyme-linked immunosorbent assay.Results The serum level of ANGPTL4 in patients with acute cerebral infarction was 1052.75 (586.53,1823.68)pg/ml,which was significantly higher than 876.18 (571.01,1528.93)pg/ml in the control group (P=0.042).The serum level of ANGPTL4 in the unstable plaque group was 794.73 (531.5,1580.06)pg/ml,which was lower than 1491.75(895.39,3960.34)pg/ml in the stable plaque group and 1223.34 (851.66,3018.70)pg/ml in the non Plaque group (P<0.05).There was no significant difference in the serum level of ANGPTL4 between plaque free group and stable plaque group (P=0.244).Spearman correlation analysis showed that the serum level of ANGPTL4 was related to HDL (r=0.194,P<0.05).Conclusion ANGPTL4 is closely related to the degree of carotid atherosclerosis,which may be a protective index of acute cerebral infarction and atherosclerosis.
- Full text:2024080122463405083Expression of Angiopoietin-like protein 4 and its relationship with carotid atherosclerosis in patients with acute cerebral infarction.pdf
