Evaluation of the efficacy of QSM combined with DKI in the treatment of Parkinson’s disease with dopamine receptor agonist
- VernacularTitle:帕金森病治疗前后QSM及DKI改变
- Author:
Yanhua CHENG
1
;
Ying CHANG
1
;
Jie LEI
1
Author Information
- Publication Type:Journal Article
- Keywords: Quantitative magnetic sensitivity imaging; Dispersion kurtosis imaging; Madopar; Parkinson’s disease
- From: Journal of Apoplexy and Nervous Diseases 2020;37(11):994-998
- CountryChina
- Language:Chinese
- Abstract: Objective To evaluate the efficacy of QSM combined with DKI in the treatment of Parkinson’s disease. Methods In June 2016 to December 2018 in the Beihua University neurology patients diagnosed with Parkinson’s disease of 60 cases and 20 healthy volunteers as control group. All patients taking Madopar，UPDRS score，magnetic sensitive quantitative imaging （QSM），and diffusion kurtosis imaging （DKI） were performed before and six months after treatment to evaluate the changes of patients’ condition. All volunteers underwent magnetic sensitivity quantitative imaging （QSM） and diffusion kurtosis imaging （DKI） examination. Two doctors manually drew the range of ROI for the deep nuclear masses of both cerebral hemispheres：substantia nigra，red nucleus，putamen，caudate nucleus，thalamus and globule，and measured the mean kurtosis （MK） value of DKI parameters and the value of magnetic susceptibility. Statistical analysis was performed on the relevant data. Results There were no lateral differences in the magnetic susceptibility and MK values of each nuclear group before and after treatment （P>0.05），The patient was treated with madopar for six months，the UPDRS score of the patients was （17.0±0.87），significantly lower than that of （19.0±0.68） before treatment，and the difference was statistically significant （P<0.05），Before treatment，the magnetic susceptibility of bilateral substantia nigra，red nucleus，shell nucleus，caudate nucleus and globus pallidus was significantly higher than that of normal control group （P<0.05），the magnetic susceptibility values of bilateral substantia nigra and putamen decreased compared with that before treatment，and the difference was statistically significant （P<0.05），the MK values of bilateral substantia nigra，left red nucleus，left caudate nucleus and bilateral colliculus before treatment were significantly higher than those of normal group （P<0.05），after treatment，the MK values of the left melanocytes，red nuclei and right melanocytes were 0.936±0.430，0.883±0.377 and 1.017±0.474，respectively，which were significantly higher than that before treatment （0.588±0.216，0.581±0.235 and 0.603±0.210），with statistically significant differences （P<0.05）. Finally，when comparing the correlations of UPDRS score with MK value and susceptibility value，the susceptibility value of the patient’s left putamen was significantly correlated with the patient’s UPDRS score （P<0.05）. Conclusion Madopar has a good effect in the treatment of Parkinson’s disease. QSM combined with DKI provides an objective basis for the detection of Madopar efficacy，among which the magnetization value of the left putamen has a significant correlation with UPDRS score.
- Full text:2024073115255628555帕金森病治疗前后QSM及DKI改变.pdf
