Exosomes and their dual role under viral infection

VernacularTitle:外泌体及其在病毒感染下的双重作用
Author: Qianqian WEI ¹ ; Limin CHEN ; Yujia LI ; Shilin LI
Author Information

1. 中国医学科学院北京协和医学院输血研究所,四川成都 610052
Keywords: exosomes; virus; ESCRT; autophagy; immunity
From: Chinese Journal of Blood Transfusion 2024;37(7):831-838
CountryChina
Language:Chinese
Abstract: Exosomes are extracellular vesicles that are released from the cell into the extracellular microenvironment,and are a carrier of biological information transmitted over long distances,which have a dual regulatory effect on the immune system.Studies have shown that viruses can hold the endosomal-exosomal pathway hostage to spread.This review describes the role played by exosomes in viral infections.On the one hand,exosomes can transmit antiviral substances and trigger im-mune responses against viral infections,and on the other hand,exosomes can serve as potential mediators of viral transmis-sion,which have been shown to be closely related to the transmission and immune escape of a variety of viruses.Understand-ing the role of exosomes in viral infections is essential for the detection of viruses in the blood,for improving blood safety,and for the search and development of antiviral drugs.