A comparative study of rapid eye movement sleep behavior disorders on Parkinson’s disease and multiple system atrophy Parkinsonism type
- VernacularTitle:帕金森病与多系统萎缩帕金森症型快速眼球运动睡眠行为障碍的比较研究
- Author:
Shuhua LI
1
;
Wen SU
1
;
Ying JIN
1
Author Information
- Publication Type:Journal Article
- Keywords: Parkinson’s disease ； DJ-1 ； SUMO-1 ； A39S ； Mitochondria
- From: Journal of Apoplexy and Nervous Diseases 2021;38(9):777-780
- CountryChina
- Language:Chinese
- Abstract: Objective To compare the differences in incidence of rapid eye movement sleep behavior disorder（RBD）on Parkinson’s disease（PD） and multiple system atrophy parkinsonism type（MSAP），and to investigate the correlation factors of the RBD screening questionnaire （RBDSQ） scores.Methods Thirty-four PD patients and 30 MSAP patients without dementia within 5 years of onset were included. Baseline data were collected in detail，and UPDRS Ⅲ score，HY staging score and RBDSQ score were performed between the two groups to compare the difference in the incidence of RBD between the two groups，as well as the correlation factors of RBDSQ score.Results The incidence of RBD in prodrome MSA （40.0%） was significantly higher than that in prodrome PD （2.9%，χ2=11.330，P=0.001）.The incidence of RBD in the clinical stage of MSAP（63.3%）was significantly higher than that in the clinical stage of PD（29.4%，χ2=7.401，P=0.007）.The RBDSQ score of MSAP patients was significantly higher than that of PD patients （6.6±3.9 vs.4.7±3.4，Z=-2.084，P=0.037）.There was no clear correlation between RBDSQ scores in PD group or MSAP group and disease course，UPDRS Ⅲ score，MMSE score and disease progression rate. Conclusion Compared with PD group，the incidence of RBD in prodrome and clinical MSAP group was significantly higher than that in PD group. In MSAP patients and PD patients with normal cognitive function，there was no clear correlation between RBDSQ score and UPDRS Ⅲ score and MMSE score.
- Full text:2024072909562135259帕金森病与多系统萎缩帕金森症型快速眼球运动睡眠行为障碍的比较研究.pdf
