Application of the multimode imaging in different stages of Alzheimer’s disease
- VernacularTitle: 多模态影像学在不同阶段阿尔茨海默病中应用研究
- Author:
Hui CAO
1
;
Yuechun LI
1
Author Information
- Publication Type:Journal Article
- Keywords: Alzheimer’s disease; Multimodal imaging; Diffusion tensor imaging; Positron emission computed tomography
- From: Journal of Apoplexy and Nervous Diseases 2022;39(1):52-58
- CountryChina
- Language:Chinese
- Abstract: To evaluate the application value of multimodal imaging technology in patients with Alzheimer’s disease at different stages. Methods A total of 56 subjects from December 1，2016 to November 30，2018 in the Department of Neurology of Baotou central hospital were recruited. According to the inclusion criteria and exclusion criteria，18 patients with mild cognitive impairment （MCI group），18 patients with Alzheimer’s disease （AD group） and 20 healthy volunteers （normal group） were enrolled. All subjects were assessed by MMSE，MOCA and neuropsychological scale，and then brain magnetic resonance imaging （MRI） and diffusion tensor imaging （DTI） were performed. Five patients were further examined by PET / CT，and the differences in multimodal imaging in different stages of Alzheimer’s disease were analyzed，so as to provide an objective basis for diagnosis and staging. Results （1） The results showed that the connectivity of AD group was significantly less than that of MCI group and normal group；there was no significant difference between MCI group and normal group，and there was no significant difference in the connection between MCI group and normal group；（2） MCI group and normal group，after regression of covariates such as age and gender among ad group the graph theory index was calculated，and the results of global attribute index among the three groups were not statistically significant；（3） There were significant differences between MCI group and ad group （P<0.05）；（4） There were significant differences between normal group and ad group （P<0.05）；（5） between normal group and MCI group，there were significant differences in five indexes （P<0.05） （6） Compared with MCI patients，AD patients showed diffuse and symmetrical glucose metabolism decrease with the increase of cognitive impairment，mainly concentrated in the cognitive related brain areas such as the silent pattern network，frontal lobe，temporal lobe and parietal lobe. （7） In different stages of Alzheimer’s disease，PET / CT and DTI may have node attributes and glucose metabolism changes in the default mode network，frontal lobe，temporal lobe and parietal lobe. Conclusion （1）In different stages of Alzheimer’s disease patients，diffusion tensor imaging node attributes are different；PET / CT with different cognitive domain affected，directly reflect the brain glucose metabolism changes，in order to assist the early diagnosis and staging of the disease；（2） Multimodal imaging in the process of Alzheimer’s disease can provide imaging basis for structural and functional changes.
- Full text:2024072722393478967多模态影像学在不同阶段阿尔茨海默病中应用研究.pdf
