The clinical value of eye-neck integrated ultrasound in idiopathic intracranial hypertension and cerebral venous sinus thrombosis
- VernacularTitle:眼-颈一体超声在特发性颅内压增高及颅内静脉窦血栓中的应用价值
- Author:
Li LIU
1
;
Lijuan WANG
1
;
Jiayu FAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Idiopathic intracranial hypertension; Cerebral venous sinus thrombosis; Ultrasound; Optic nerve sheath diameter; Blood flow volume
- From: Journal of Apoplexy and Nervous Diseases 2022;39(1):4-7
- CountryChina
- Language:Chinese
- Abstract: The clinical presentation of cerebral venous sinus thrombosis （CVST） overlaps with that of idiopathic intracranial hypertension （IIH），but no screening tool exists. We investigated the role of eye-neck integrated ultrasound in the diagnosis and differentiation of IIH and CVST. Methods Twenty IIH patients，25 CVST patients，and 40 healthy controls were retrospectively analyzed.The ultrasonographic optic nerve sheath diameter （ONSD） and hemodynamic characteristics of the internal jugular veins（IJVs）were recorded. The cerebrospinal fluid opening pressure was measured after ultrasonic examination.Results The ONSD was significantly larger in IIH patients than in controls （4.71±0.41 vs. 3.93±0.24 mm，P<0.001）.The ONSD cut off for IIH diagnosis was 4.25 mm （AUC=0.978，95%CI 0.95～1.00，P<0.001，sensitivity：90%，specificity：93%）.In the CVST group，19 （76%） patients had elevated intracranial pressure （ICP）；the mean ONSD was significantly higher in patients with increased ICP than in those without （4.35±0.22 vs. 3.96±0.18 mm，P<0.001）.The mean blood flow volume （BFV） was significantly reduced in CVST patients （404.43±314.73 mL/min） compared to that in controls（680.37±233.03 mL/min，P<0.001） and IIH patients （617.67±282.96 ml/min，P=0.008）. The optimal BFV cut off for predicting CVST was 471.60 ml/min（AUC=0.841，95%CI 0.73～0.95，P<0.001，sensitivity：88%，specificity：72%）.No difference in frequency of IJVVI between patients and controls. Conclusion Eyeneck integrated ultrasound is an easily available bedside technique to assess ICP and hemodynamic characteristics of IJVs.ONSD measurement can identify patients with increased ICP，and reduced IJV BFV may aid the differentiation of CVST and IIH.
- Full text:2024072709471431817The clinical value of eyeneck integrated ultrasound in idiopathic intracranial hypertension and cerebral venous sinus thrombosis.pdf
