Efficacy of traditional Chinese medicine compound on amenorrhea in female patients with schizophrenia caused by antipsychotic drugs:a Meta-analysis
10.11886/scjsws20230718001
- VernacularTitle:中药复方对抗精神病药物所致女性精神分裂症患者闭经的疗效的Meta分析
- Author:
Qi WU
1
;
Qi ZHOU
;
Li ZHANG
;
Xiaojuan ZHANG
;
Hongqiang ZHANG
Author Information
1. 兰州市第三人民医院,甘肃 兰州 730050
- Keywords:
Antipsychotic-induced amenorrhea;
Traditional Chinese medicine compound;
Clinical efficacy;
Meta-analysis
- From:
Sichuan Mental Health
2024;37(3):282-288
- CountryChina
- Language:Chinese
-
Abstract:
Background The incidence of mental disorders is steadily increasing.However,antipsychotic medications,commonly used in treatment,can lead to drug-induced amenorrhea in female patients.This side effect significantly reduces medication adherence and increases the risk of disease recurrence.Therefore,addressing drug-induced amenorrhea in female patients has become an urgent problem requiring effective solutions.Objective To explore the efficacy and safety of traditional Chinese medicine compound in treating antipsychotic-induced amenorrhea,so as to provide guidance for the treatment of this condition using traditional Chinese medicine compound.Methods On September 4,2022,a computerized search was conducted on across multiple databases,including China National Knowledge Infrastructure,VIP Database,Wanfang Database,China Biomedical Literature Database,PubMed,Cochrane Library and Embase,and randomized controlled trials(RCT)of traditional Chinese medicine compound in treating antipsychotic-induced amenorrhea were collected.The quality of the included literature was assessed using Cochrane 5.3 bias risk assessment tool.Meta-analysis was performed to assess the total effective rate,cure rate,incidence of adverse reactions and recurrence rate using RevMan 5.3.Results Ultimately,22 RCT involving 1879 patients were included.Meta-analysis results showed that the total effective rate(RR=1.29,95%CI:1.16～1.44)and cure rate(RR=1.62,95%CI:1.45～1.80)of traditional Chinese medicine compound or its combination with western medicine in treating antipsychotic-induced amenorrhea were significantly higher compared to western medicine alone.Moreover,the incidence of adverse reactions(RR=0.56,95%CI:0.41～0.76)and recurrence rate(RR=0.16,95%CI:0.06～0.42)were significantly lower than those of western medicine alone.Conclusion Traditional Chinese medicine compound may offer benefits in ameliorating antipsychotic-induced amenorrhea and its safety is better than simple western medicine treatment.
