Association of single nucleotide polymorphisms of PTPRD and restless legs syndrome：a Meta-analysis
- VernacularTitle:PTPRD单核苷酸多态性与不宁腿综合征相关性的Meta分析
- Author:
Jun ZHANG
1
;
Gen LI
1
;
Pei WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: PTPRD; Restless legs syndrome; Single nucleotide polymorphism; Meta-analysis
- From: Journal of Apoplexy and Nervous Diseases 2022;39(3):206-209
- CountryChina
- Language:Chinese
- Abstract: The aim of the study is to investigate the association of rs1975197 and rs4626664 of PTPRD and restless legs syndrome （RLS）.Methods We retrieved 4 studies on rs1975197 and 5 studies of rs4626664 and extracted basic information of each study following inclusion and exclusion criteria. Meta-analysis was used to analyze odds ratio（OR）and 95% confidence intervals（CI）.Forest plots were used to assess heterogeneity visually.If heterogeneity existed，subgroup analysis would be used. Funnel plots was used to assess publication bias visually.Results As for rs1975197，T allele could increase the risk of RLS in Caucasian（OR=1.43，95%CI 1.13～1.80）.However，there were no statistically significant of rs4626664 observed in neither overall analysis nor subgroup analysis.Conclusion T allele of rs1975197 of PTPRD increases the risk of RLS in Caucasian using Meta-Analysis，suggesting a race specificity of PTPRD with RLS. More and larger case-control studies including different races need to be launched for investigating the association of PTPRD with RLS.
- Full text:2024072610000670739PTPRD单核苷酸多态性与不宁腿综合征相关性的Meta分析.pdf
