Application of Mitochondrial Targeting Strategy of Nano-delivery System in Tumor Diagnosis and Treatment
10.16476/j.pibb.2022.0628
- VernacularTitle:纳米递送系统线粒体靶向策略在肿瘤诊疗中的应用
- Author:
Jun QU
1
;
Shuang YAN
1
;
Long-Tian-Yang LEI
1
;
Fei-Jun OUYANG
1
;
Hai-Tao ZHANG
1
;
Xu-Ping QIN
1
Author Information
1. Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421001, China
- Publication Type:Journal Article
- Keywords:
mitochondria;
targeted therapy;
tumor therapy;
tumor diagnosis;
nanocarriers
- From:
Progress in Biochemistry and Biophysics
2024;51(1):70-81
- CountryChina
- Language:Chinese
-
Abstract:
Tumor is one of the major diseases that endanger people’s health. At present, the treatments used for tumor include surgery, chemotherapy, radiotherapy and so on. Nonetheless, the traditional treatments have some disadvantages, such as insufficient treatment effect, liable to cause multidrug resistance, toxicity and side effect. Further research and exploration of tumor treatment schemes are still necessary. As the energy converter of cells, mitochondria are currently considered to be one of the most important targets for the design of new drugs for tumor, cardiovascular and neurological diseases. Nano-drug delivery carriers have the characteristics of being easily modified with active targeting groups, and it can achieve accurate targeted drug delivery to cells and organelles. This paper reviews the application of mitochondrial targeted nanoparticles in tumor diagnosis and treatment from the aspects of inhibiting tumor cell proliferation, promoting tumor cell apoptosis, inhibiting tumor recurrence and metastasis, and inducing cell autophagy.
