Exploration of serum MMP-9 and miR-221 expression in patients with acute cerebral infarction and clinical value
- VernacularTitle:急性脑梗死患者血清MMP-9、miR-221表达水平检测及临床价值探索
- Author:
Jiajia FENG
1
;
Dan LIU
1
;
Guangwei ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Acute cerebral infarction; miR-221; MMP-9; ROC curve
- From: Journal of Apoplexy and Nervous Diseases 2022;39(6):523-526
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the expression levels and clinical value of serum matrix metalloproteinase-9 (MMP-9) and miR-221 in patients with acute cerebral infarction.Methods Fifty patients with acute cerebral infarction admitted to our department were selected as the case group,and 50 healthy subjects were selected as the control group.The expression levels of serum miR-221 in the two groups of subjects were detected by qRT-PCR method,and the content of serum MMP-9 was detected by ELISA method,and the diagnostic value of the combined detection of the two in acute cerebral infarction was analyzed.Results Compared with the control group,the expression levels of serum MMP-9 and miR-221 in the case group were significantly increased (P<0.01).MMP-9 and miR-221 were positively correlated with acute cerebral infarction,and MMP-9 and miR-221 were independent risk factors for acute cerebral infarction.The AUC of combined detection was significantly higher than that of single detection (P<0.05).Conclusion Serum MMP-9 and miR-221 are closely related to the occurrence of acute cerebral infarction,and their combined detection is expected to become a new combined target for early diagnosis of acute cerebral infarction.
- Full text:2024072421321149763Exploration of serum MMP-9 and miR-221 expression in patients with acute cerebral infarction and clinical value.pdf
