Spatial and temporal heterogeneity of pathological phenotype of EGFR - mutant transformed locally advanced or metatsatic small-cell lung cancer or neuroendocrine carcinoma
10.19405/j.cnki.issn1000-1492.2022.12.023
- Author:
Shiling Zhang
1
;
Chanyuan Zhang
1
;
Yuqing Chen
2
;
Jinj Yang
1
Author Information
1. The Second School of Clinical Medicine，Southern Medical University，Guangzhou 510515;Guangdong Lung Cancer Institute，Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer，Guangdong Provincial People 's Hospital，Guangdong Academy of Medical Sciences，Guangzhou 510080
2. Guangdong Lung Cancer Institute，Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer，Guangdong Provincial People 's Hospital，Guangdong Academy of Medical Sciences，Guangzhou 510080;School of Medicine，South China University of Technology，Guangzhou 510006
- Publication Type:Journal Article
- Keywords:
EGFR mutation;
small-cell lung cancer;
neuroendocrine carcinoma;
histological transformation;
spa- tial and temporal heterogeneity
- From:
Acta Universitatis Medicinalis Anhui
2022;57(12):1985-1990
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the spatial and temporal heterogeneity of pathological phenotype of epidermal growth factor receptor (EGFR) -mutant transformed locally advanced or metastatic small-cell lung cancer( SCLC) or neuroendocrine carcinoma (NEC) ．
Methods :This study retrospectively analyzed EGFR-mutant LUAD patients who were treated with EGFR-TKIs and underwent a transformation into SCLC / NEC． Baseline clinicopathological characteristics after initial transformation were summarized．According to the different pathological components of initial SCLC / NEC transformation，it was defined as incomplete transformation and complete transformation．Incom- plete transformation was defined as three categories : intratumoral transformation，intertumoral transformation and ef- fusional transformation.
Results :This study collected 49 patients who met the criteria．Among forty-nine patients， incomplete transformation was 34. 7% ( 17 /49) and complete transformation was 65. 3% (32 /49) ．In addition， intratumoral transformation ，intertumoral transformation and effusional transformation were respectively 82. 3% ( 14 /17) ，5. 9% ( 1 /17) and 11. 8% (2 /17) . It was mean that the spatial heterogeneity of pathological phenotype of initially transformed SCLC / NEC was 34. 7%．After initial transformation，among the fifteen patients in dynamic histological and / or cytological biopsies，the temporal heterogeneity of pathological phenotype of initially transformed SCLC / NEC was 46. 7% (7 /15) ．In addition，there was no significant difference in first-line treatment post-trans- formation progression-free survival and post-transformation overall survival between incomplete transformation group and complete transformation group．
Conclusion : EGFR-mutant transformed locally advanced or metaststic SCLC / NEC has spatial and temporal heterogeneity in pathological phenotype.
- Full text:2024072222204193939EGFR突变转化型晚期小细...分泌癌的病理表型时空异质性_张仕灵.pdf
