Research progress on the role of tolerogenic dendritic cells in immune tolerance of liver transplantation
10.3969/j.issn.1674-7445.2024039
- VernacularTitle:耐受性树突状细胞在肝移植免疫耐受中的作用研究进展
- Author:
Zhiqi YANG
1
;
Minghao LI
Author Information
1. 750002 银川,宁夏医科大学第三临床医学院;宁夏回族自治区人民医院肝胆外科
- Keywords:
Dendritic cell;
Liver transplantation;
Immune tolerance;
Rejection;
Immunosuppressant;
Cytokine;
Costimulatory molecule;
Cross modification;
Immune microenvironment
- From:
Organ Transplantation
2024;15(4):575-580
- CountryChina
- Language:Chinese
-
Abstract:
Rejection after liver transplantation severely affects the survival of recipients.Long-term use of immunosuppressants is an important approach to prevent rejection,whereas it may cause toxic effects and increase the risk of adverse events such as systemic infection and tumor recurrence,etc.Therefore,before successful liver transplantation,how to induce individual immune tolerance of recipients and achieve complete or early withdrawal of postoperative immunosuppressants remains to be investigated by practitioners of organ transplantation.In recent years,certain progresses have been made in the mechanism of immune tolerance induced by tolerogenic dendritic cells in liver transplantation,and preliminary outcomes have been obtained in clinical trials.In this article,basic research and clinical application progress in the characteristics of tolerogenic dendritic cells,the mechanism underlying participating in liver immune microenvironment remodeling,and inducing immune tolerance in liver transplantation were reviewed,aiming to provide reference for the application of tolerogenic dendritic cells in immune tolerance of liver transplantation.
