Factors correlating to frozen⁃thawed embryo transfer outcomes in preimplantation genetic testing cycles
10.19405/j.cnki.issn1000-1492.2023.01.023
- Author:
Xiaoqian Zhu
1
;
Wenjuan Xu
1
;
Ping Zhou
1
Author Information
1. Dept of Obstetrics and Gynecology, The First Afiliated Hospital of Anhui Medical University, Hefei 230022 ; Key Laboratory of Gametes and Reproductive Tract Abnormalities , National Health Commission , Hefei 230032 ; Key Laboratory ofMinistry of Birth Health Education , Hefei 230032
- Publication Type:Journal Article
- Keywords:
preimplantation genetic testing;
transplant outcomes;
insulin;
triglycer⁃ides;
hormone replacement therapy cycles
- From:
Acta Universitatis Medicinalis Anhui
2023;58(1):140-144
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the factors associated with the transplant outcomes after the treatment of preimplantation genetic testing (PGT) for infertile patients.
Methods: A retrospective analysis of data of frozen⁃thawed embryo transfers in PGT for structural rearrangements/PGT for monogenic ( PGT⁃SR/PGT⁃M) cycles was performed. According to the transplant outcomes , it was divided into the pregnancy group (74 cases) and the nonpregnancy group (74 cases) . The factors including male age , female age , duration of infertility , number of abortion , female BMI , follicle⁃stimulating hormone (FSH) , luteinizing hormone ( LH) , estradiol( E2) , progesterone(P) , blood glucose , insulin , albumin , total cholesterol , triglycerides , high⁃density lipoprotein( HDL) , parents ′causes of infertility , type of chromosomal abnormality , number of retrieved oocyte , number of meiosis II( MII) , number of fertilization , number of two pronuclei(2PN) , endometrial thickness on embryo transfer day , endometrial preparation , day of embryo development , presence of a top quality embryo ( TQE) or not were analyzed by the Mann⁃Whitney U test and Pearson ′s chi⁃square test. The probability of transplant outcomes in correlation with the relevant parameters analyzed was measured with multivariate logistic regression analysis.
Results:Univariate analysis indicated that E2 , insulin , total cholesterol , triglycerides and endometrial preparation were significantly associated with transplant outcomes in PGT⁃SR , PGT⁃M cycles (P < 0. 05) . Multiple logistic regression analysis revealed that lower levels of insulin ( OR = 0. 14 , 95% CI = 0. 03 - 0. 27) and triglycerides ( OR = 1. 38 , 95% CI = 0. 14 -2. 78) in women were beneficial to transplant outcomes in PGT cycles. For endometrial preparation , compared with natural cycles , hormone replacement therapy (HRT) cycles ( OR = 3. 52 , 95% CI = 2. 54 - 4. 65) were another factor to improve transplant outcomes.
Conclusion:There is a correlation between the levels of insulin and triglycerides , endometrial preparation and transplant outcomes in PGT cycles. In detail , lower levels of insulin and triglycerides , and the HRT cycle can lead to a better transplant outcome.
- Full text:2024071221514126413胚胎植入前遗传学检测治疗后移植结局相关因素分析_朱晓倩.pdf
