Effect of heparin-binding protein on vascular permeability in patients with sepsis
10.3969/j.issn.1673-9701.2024.10.008
- VernacularTitle:肝素结合蛋白对脓毒症患者血管通透性影响的研究
- Author:
Xiuqi ZHU
1
Author Information
1. Department of Intensive Care Medicine, Affiliated Jinhua Hospital Zhejiang University School of Medicine, Jinhua 321000, Zhejiang, China
- Publication Type:Journal Article
- Keywords:
Sepsis;
Heparin-binding protein;
Vascular permeability;
Fluid overload
- From:
China Modern Doctor
2024;62(10):32-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between heparin-binding protein(HBP)and vascular permeability in patients with sepsis.Methods Four hundred infected patients admitted to Affiliated Jinhua Hospital Zhejiang University School of Medicine from November 2019 to November 2022 were retrospectively selected and divided into sepsis group(n=190)and non-sepsis group(n=210)according to whether they were diagnosed with sepsis or not.HBP,the difference between hematocrit(HCT)and serum albumin(ALB)(HCT-ALB)and percentage of fluid overload were compared between two groups.Pearson method was used to analyze the correlation between HBP,HCT-ALB and percentage of liquid overload.Results HBP,HCT-ALB and percentages of fluid overload in sepsis group were significantly higher than those in non-sepsis group(P<0.05).Pearson correlation analysis showed that serum HBP level was positively correlated with HCT-ALB and percentage of fluid overload 24h after admission(P<0.05).Conclusion Increased vascular permeability in patients with sepsis may be related to the high level of HBP released by neutrophils stimulated by bacterial toxins.
