Expression of MutS homolog 3 in oral squamous cell carcinoma and its significance
10.3969/j.issn.1673-9701.2024.02.006
- VernacularTitle:错配修复蛋白3在口腔鳞状细胞癌中的表达及意义
- Author:
Xiaofei XIU
1
;
Feng GAO
1
;
Xiaomei WANG
1
;
Jiaman XU
2
;
Xuelan XIAO
1
;
Dawei WANG
2
Author Information
1. Department of Pathology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China
2. Department of Oral surgery, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China
- Publication Type:Journal Article
- Keywords:
MutS homolog 3;
Oral squamous cell carcinoma;
Immunohistochemistry;
Differentiation;
Metastasis
- From:
China Modern Doctor
2024;62(2):26-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of MutS homolog 3(MSH3)in oral squamous cell carcinoma and its significance.Methods The MSH3 protein expression was examined by immunohistochemistry in 20 normal oral mucosa and 60 oral squamous cell carcinoma tissues.Results Our results showed that MSH3 expression in oral squamous cell carcinoma tissues was lower than normal oral mucosa.The MSH3 expression in oral squamous cell carcinoma tissues with better differentiation was higher than that with worse differentiation.The positive MSH3 expression decreased from oral squamous cell carcinoma patients without lymph nodal metastasis to that with metastasis.MSH3 expression was not related to the patients'gender,age,tumour location or size.Conclusion Downregulation of MSH3 is consistent with poorly differentiation and nodal metastasis in oral squamous cell carcinoma.MSH3 may play a significant role in the malignant progression of oral squamous cell carcinoma.
