A retrospective study:The efficacy and safety of immunotherapy combined with radiochemotherapy for advanced esophageal cancer
10.3969/j.issn.1673-9701.2024.01.010
- VernacularTitle:免疫治疗联合放化疗对晚期食管癌疗效及安全性的回顾性研究
- Author:
Bingbing LI
1
;
Mingjun ZHANG
1
Author Information
1. Department of Medical Oncology, the Second Hospital of Anhui Medical University, Hefei 230601, Anhui, China
- Publication Type:Journal Article
- Keywords:
Esophageal cancer;
Immune checkpoint inhibitor;
Adverse reaction;
Therapeutic effect
- From:
China Modern Doctor
2024;62(1):39-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To contrast the efficacy and safety of immune checkpoint inhibitor(ICI)combined with radiochemotherapy and concomitant radiochemotherapy in the treatment of advanced esophageal cancer.Methods The clinical data of 67 patients with advanced esophageal cancer who were treated in the Second Hospital of Anhui Medical University from January 2019 to January 2023 were retrospectively analyzed.Patients were divided into combination group(n=35)and radiochemotherapy group(n=32)according to different treatment plans.Progress free survival(PFS),objective remission rate(ORR),disease control rate(DCR)and adverse reactions were compared between two groups.Results The median PFS in combination group was significantly longer than that in radiochemotherapy group(12.6 months vs.6.3 months,χ2=16.288,P<0.001).ORR in combination group was significantly higher than that in radiochemotherapy group(54.3%vs.21.9%,P=0.011).DCR in combination group was significantly higher than that in radiochemotherapy group(77.1%vs.53.1%,P=0.045).The incidence of treatment-related adverse reactions and radiochemotherapy-related adverse reactions in combination group were significantly lower than those in radiochemotherapy group(P<0.05).There were 11 cases of immune-related adverse reactions in combination group,all of which were grade 1-2 adverse reactions.Conclusion ICI combined with radiochemotherapy can improve the curative effect of patients with advanced esophageal cancer,and the adverse reactions are acceptable.
