Change and clinical significance of IL-17 and hypersensitive c-reactive protein level of bronchial asthma patients with acute episodes
- VernacularTitle:支气管哮喘急性发作期患者白细胞介素（IL-17）及超敏C反应蛋白的水平变化及临床意义
- Author:
Yihua QIN
1
Author Information
1. 广东省茂名市茂南区人民医院内二科
- Keywords:
Bronchial asthma;
Acute episodes;
Interleukin-17;
Hypersensitive C-reactive protein
- From:
China Modern Doctor
2014;(18):23-25,29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study change and clinical significance of IL-17 and hypersensitive c-reactive protein level of bronchial asthma patients with acute episodes. Methods A total of 90 cases of asthma patients with acute phase were selected as the research objects of this study. 46 patients in asthma patients with acute episodes were randomly select-ed as asthma remission group. 48 cases of healthy crowd were selected as control group. Serum IL-17 and hs-CRP lev-els in three groups were compared. Serum IL-17 and hs-CRP levels of asthma patients with acute phase before and af-ter treatment were compared. Relationship between serum IL-17 and hs-CRP levels with pulmonary function in pa-tients were analyzed. Results Serum hs-CRP and IL-17 levels of three groups of patients had significant difference (P=0.0000); Acute phase serum hs-CRP and IL-17 levels of patients were obviously higher than that of remission group and the control group (all P <0.01); Serum hs-CRP and IL-17 levels of patients in remission group were higher than the control group(P<0.01). After treatment serum hs CRP, IL-17 levels of asthma patients with acute phase significant-ly lower than before treatment (P<0.01). Serum hs-CRP, IL-17 levels negatively correlated with FEV1 % of expected value. Serum hs-CRP, IL-17 level negatively correlated with FEV1/FVC. Serum hs-CRP, IL-17 levels were positively related with the ACT. Conclusion IL-17, hs-CRP levels of asthma patients with acute phase serum increased signifi-cantly. Asthma patients' serum hs-CRP, IL-17 levels closely related to pulmonary function.
