Traditional Chinese Medicine Intervention of Signaling Pathways in Chronic Obstructive Pulmonary Disease： A Review
10.13422/j.cnki.syfjx.20241021
- VernacularTitle:中医药干预慢性阻塞性肺疾病相关信号通路的研究进展
- Author:
Yang YANG
1
;
Zhuying LI
2
;
Chunyan TIAN
2
;
Xing LI
2
Author Information
1. Heilongjiang University of Chinese Medicine，Harbin 150040，China
2. First Affiliated Hospital， Heilongjiang University of Chinese Medicine，Harbin 150040，China
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
signaling pathways;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(15):244-255
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease （COPD） is a heterogeneous disease characterized by incompletely reversible airflow limitation that progresses over time. Its recurrent and incurable nature imposes a significant health burden on patients. The pathogenesis of COPD is complex and has not been fully elucidated. Currently， Western medicine is commonly used in clinical treatment， which often yield suboptimal results and may lead to adverse reactions and drug resistance. Therefore， finding an effective and safe treatment method is a crucial focus in medical research. With the ongoing advancement in disease research， many scholars have discovered that traditional Chinese medicine （TCM） can target various signaling pathways such as nuclear factor-kappa B （NF-κB）， phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt）， mitogen-activated protein kinase （MAPK）， neurogenic locus notch homolog protein （Notch）， Janus kinase （JAK）/signal transducer and activator of transcription （STAT）， transforming growth factor-β （TGF-β）/Smad， secreted glycoprotein （Wnt）， Hippo， and nuclear factor erythroid 2-related factor 2 （Nrf2）. By influencing these pathways， TCM can affect airway mucus secretion， inhibit inflammation and oxidative stress， alleviate airway and microvascular remodeling， and regulate apoptosis and autophagy， ultimately reducing disease symptoms and improving lung function. TCM has thousands of years of clinical practice experience in treating COPD， demonstrating significant efficacy. Therefore， delving deeply into this from a cellular and molecular perspective can provide a reliable theoretical basis for the clinical application of TCM in treating COPD. However， systematic summaries of how TCM regulates COPD-related signaling pathways are scarce. This article aimed to extensively review and summarize recent literature in China and abroad on interventions of TCM monomers or compound prescriptions in COPD， identifying multiple related pathways to provide new insights for future clinical formulation and experimental research. Integrating basic TCM theories with modern pharmacological research mechanisms can jointly propel the development of TCM in the prevention and treatment of COPD.
