Recent advance in role of synaptosomal-associated protein-25 in neurodegenerative diseases
10.3760/cma.j.cn115354-20230610-00321
- VernacularTitle:突触小体相关蛋白-25在神经退行性疾病中的研究进展
- Author:
Jing XU
1
;
Xiaojun ZHANG
;
Jiajun CHEN
Author Information
1. 吉林大学中日联谊医院神经内科，长春 130000
- Keywords:
Synaptosome-associated protein-25;
Alzheimer's disease;
Parkinson's disease;
Lewy body dementias
- From:
Chinese Journal of Neuromedicine
2024;23(3):284-290
- CountryChina
- Language:Chinese
-
Abstract:
Synaptic dysfunction is one of the important pathophysiological mechanisms of neurodegeneration in neurodegenerative diseases, and detection of synaptic protein biomarkers is of great value in determining disease progression and clinically monitoring the efficacy of disease-modifying drugs. Synaptosome-associated protein-25 is a presynaptic plasma membrane protein that can reliably reflect synaptic damage in neurodegenerative diseases, and may be the most promising biomarker to evaluate synaptic function. This review focuses on the basic characteristics and functions of synaptosome-related protein-25 and its research progress in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Lewy body dementias, in order to identify pathological changes and early diagnosis of high-risk patients early at preclinical stage, and seek opportunities for disease monitoring and new therapeutic targets.
