Recent advance in role of circular RNA in regulating cerebral ischemia-reperfusion injury

VernacularTitle:环状RNA在调控脑缺血再灌注损伤中的作用研究进展
Author: Yu ZHOU ¹ ; Bin LI ; Yong MA ; Erqing CHAI
Author Information

1. 兰州大学第一临床医学院，兰州　730000
Keywords: Ischemic stroke; Cerebral ischemia/reperfusion injury; Circular RNA
From: Chinese Journal of Neuromedicine 2023;22(5):523-528
CountryChina
Language:Chinese
Abstract: Ischemic stroke (IS) is one of the main causes of human death and disability all over the world. Although reperfusion treatments, such as stent implantation, cerebrovascular bypass and thrombolysis, can achieve reperfusion in ischemic regions of IS patients, cerebral ischemia-reperfusion injury (CIRI) caused by reperfusion treatment has become a difficult clinical treatment problem. At present, the clinical diagnosis and treatment methods to improve CIRI are limited and often can not obtain satisfactory effect; therefore, CIRI exploration based on molecular level to find an effective method for CIRI has become the focus of current research. Studies have confirmed that circular RNA (circRNA) participates in many physiological/pathological processes in brain CIRI and acts as an important regulator, which is expected to become a potential target for CIRI treatment. This paper focuses on the regulation of circRNA in different cerebral cellular neurons to provide new potential target for CIRI treatment and improvement.