Recent advance in Toll-like receptor 4 related signaling pathway in inflammatory injury of ischemic stroke
10.3760/cma.j.cn115354-20220706-00473
- VernacularTitle:Toll样受体4相关信号通路在缺血性脑卒中炎症损伤中的研究进展
- Author:
Bin LI
1
;
Yu ZHOU
;
Yong MA
;
Erqing CHAI
Author Information
1. 甘肃中医药大学第一临床医学院，兰州 730000
- Keywords:
Toll-like receptor 4;
Ischemic stroke;
Inflammatory damage
- From:
Chinese Journal of Neuromedicine
2023;22(2):205-211
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of ischemic stroke development has not been fully elucidated, but inflammatory damage has been recognized to play an important role. Activation of Toll-like receptor 4 (TLR4)-related signaling pathways can promote the expressions of pro-inflammatory cytokines and anti-inflammatory cytokines associated with ischemic stroke, thereby affecting the progression and prognosis of ischemic stroke. The author reviews the research progress of TLR4-related signaling pathways in inflammatory injury of ischemic stroke, in order to provide some ideas and references for the discovery of targeted TLR4 anti-inflammatory drugs that can be used for ischemic stroke treatment.
